Fornace Laboratory Recent Publications and Reviews


Pannkuk EL, Fornace AJ Jr, Laiakis EC.  Metabolomic Applications in Radiation Biodosimetry: Exploring Radiation Effects Through Small Molecules. Int J Radiat Biol 2017.


Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E., and McMullen, P. D. Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity. Arch Toxicol 2016. PMID: 27592001

Goudarzi, M., Mak, T. D., Jacobs, J. P., Moon, B. H., Strawn, S. J., Braun, J., Brenner, D. J., Fornace, A. J., Jr., and Li, H. H. An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. Radiat. Res. 186: 219-234, 2016. PMID: 27512828

Kleensang, A., Vantangoli, M. M., Odwin-DaCosta, S., Andersen, M. E., Boekelheide, K., Bouhifd, M., Fornace, A. J., Jr, Li, H.-H., Livi, C. B., Madnick, S., Maertens, A., Rosenberg, M., Yager, J. D., Zhaog, L., and Hartung, T. Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function. Sci. Rep. 6: 28994, 2016. PMID: 27456714

Suman S, Kumar S, Fornace AJ, Datta K. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine. Sci Rep. 2016 Aug 25;6:31853. doi: 10.1038/srep31853. PMID: 27558773.

Suman S, Kumar S, Moon BH, Strawn SJ, Thakor H, Fan Z, Shay JW, Fornace AJ Jr, Datta K. Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorgenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice. 2016 May 1;95(1):131-8. doi: 10.1016/j.ijrobp.2015.10.057. Epub 2015 Oct 31. PMID: 26725728.

Datta, K., Suman, S., Kumar, S., and Fornace, A. J. Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway. J Cancer 7: 174-183, 2016. PMID: 26819641 PMCID: PMC4716850

Yauk, CL, Buick, JK, Williams, A, Swartz, CD, Recio, L, Li, HH, Fornace, AJ Jr., Thomson, EM, Aubrecht, J.Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9. Environ Mol Mutagen, 2016. PMID: 26946220. 

Pannkuk, E. L., Laiakis, E. C., Mak, T. D., Astarita, G., Authier, S., Wong, K., and Fornace, A. J., Jr. A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation. Metabolomics in press, 2016.

Laiakis, E. C., Pannkuk, E. L., Diaz-Rubio, M. E., Wang, Y. W., Mak, T. D., Simbulan-Rosenthal, C. M., Brenner, D. J., and Fornace, A. J., Jr. Implications of genotypic differences in the generation of a urinary metabolomics radiation signature. Mutat Res 2016. PMID: 27040378

Cheema, A. K., Maier, I., Dowdy, T., Wang, Y., Singh, R., Ruegger, P. M., Borneman, J., Fornace, A. J., Jr, and Schiestl, R. H. Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. PLoS One 11: e0151190, 2016. PMID: 27073845

Kwon, O. S., Kim, K. T., Lee, E., Kim, M., Choi, S. H., Li, H., Fornace, A. J., Cho, J. H., Lee, Y. S., Lee, J. S., Lee, Y. J., and Cha, H. J. Induction of MiR-21 by Stereotactic Body Radiotherapy Contributes to the Pulmonary Fibrotic Response. PLoS One 11: e0154942, 2016. PMID: 27171163

Pannkuk, E. L., Laiakis, E. C., Authier, S., Wong, K., and Fornace, A. J., Jr. Targeted metabolomics of nonhuman primate serum after exposure to ionizing radiation: potential tools for high-throughput biodosimetry. RSC Adv. 6: 51192-51202, 2016.

Goudarzi, M., Chauthe, S., Strawn, S. J., Weber, W. M., Brenner, D. J., and Fornace, A. J. Quantitative Metabolomic Analysis of Urinary Citrulline and Calcitroic Acid in Mice after Exposure to Various Types of Ionizing Radiation. Int J Mol Sci 17: 2016. PMID: 27213362

Laiakis, E. C., Strawn, S. J., Brenner, D. J., and Fornace, A. J., Jr. Assessment of Saliva as a Potential Biofluid for Biodosimetry: A Pilot Metabolomics Study in Mice. Radiat. Res. [Epub ahead of print], 2016. PMID: 27332953.

Chen, Z., Coy, S. L., Pannkuk, E. L., Laiakis, E. C., Hall, A. B., Fornace, A. J., Jr, and Vouros, P. Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry. J Am Soc Mass Spectrom 2016. PMID: 27392730.

Cha, H.-J., and A. J. Fornace, Jr. 2016. P38. p. 1-11. In L. J. Marshall (ed.), Cancer Therapeutic Targets. Springer New York, New York, NY, ISBN: 978-1- 4614-6613- 0.


Suman, S., Kumar, S., Fornace, A. J., and Datta, K. Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors. Front Oncol 5: 218, 2015. PMID: 26500891 PMCID: PMC4597120.

Suman, S., Moon, B. H., Thakor, H., Fornace, A. J., Jr, and Datta, K. Wip1 Abrogation Decreases Intestinal Tumor Frequency in APC Mice Irrespective of Radiation Quality. Radiat Res 2014. PMID: 25117622

Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res (Amst). 2015 Jul;6:92-103.

Goudarzi M, Weber WM, Chung J, Doyle-Eisele M, Melo DR, Mak TD, Strawn SJ, Brenner DJ, Guilmette R, Fornace AJ. Serum dyslipidemia is induced by internal exposure to strontium-90 in mice, lipidomic profiling using a data-independent LC/MS approach. J Proteome Res. 2015 Aug 11.

Li HH, Wang YW, Chen R, Zhou B, Ashwell JD, Fornace AJ Jr. Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming. Int J Biol Sci. 2015 May 15;11(7):726-36. 

Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Jr Jr. Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation. Radiat Res. 2015 Jul 31.

Goudarzi M, Weber WM, Mak TD, Chung J, Doyle-Eisele M, Melo DR, Strawn SJ, Brenner DJ, Guilmette RA, Fornace AJ Jr. A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90. Radiat Res. 2015 May 26.

LaConti JJ, Laiakis EC, Mays A, Peran I, Kim S, Shay JW, Riegel AT, Fornace AJ, Wellstein A. Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma. BMC Genomics. 2015;16 Suppl 1:S1. doi: 10.1186/1471-2164-16-S1-S1. Epub 2015 Jan 15.

Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW. Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. BMC Genomics. 2015;16 Suppl 1:S8. doi: 10.1186/1471-2164-16-S1-S8. Epub 2015 Jan 15.

Mak, T. D., Laiakis, E. C., Goudarzi, M., and Fornace, A. J., Jr. Selective Paired Ion Contrast Analysis: A Novel Algorithm for Analyzing Postprocessed LC-MS Metabolomics Data Possessing High Experimental Noise. Anal Chem 2015. 

Bouhifd M, Andersen ME, Baghdikian C, Boekelheide K, Crofton KM, Fornace AJ Jr, Kleensang A, Li H, Livi C, Maertens A, McMullen PD, Rosenberg M, Thomas R, Vantangoli M, Yager JD, Zhao L, Hartung T. The human toxome project. ALTEX. 2015;32(2):112-24. doi: Epub 2015 Mar 4.

Suman, S., Kallakury, B. V. S., Fornace, A. J., Jr, and Datta, K. Protracted Upregulation of Leptin and IGF1 is Associated with Activation of PI3K/Akt and JAK2 Pathway in Mouse Intestine after Ionizing Radiation Exposure. Int J Biol Sci 11: 274-283, 2015. 

Laiakis, E. C., Trani, D., Moon, B. H., Strawn, S. J., and Fornace, A. J., Jr. Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences. Radiat Res.Radiat Res. 2015 Mar 13.

Buick, J. K., Moffat, I., Williams, A., Swartz, C. D., Recio, L., Hyduke, D. R., Li, H.-H., Fornace, A. J., Jr, Aubrecht, J., and Yauk, C. L. Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells: Transcriptomic Genotoxicity Signature. Environ. Mol. Mutagen. online in press, 2015. 

LaConti, J. J., Laiakis, E. C., Deslattes Mays, A., Peran, I., Kim, S. E., Shay, J. W., Riegel, A. T., Fornace, A. J., Jr, and Wellstein, A. Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic duct adenocarcinoma. BMC Genomics. 2015;16:6935.

Li, H. H., Hyduke, D. R., Chen, R. X., Heard, P., Yauk, C. L., Aubrecht, J., and Fornace, A. J., Jr. Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells. Environ Mol Mutagen in press, 2015. 

Moffat, I., Chepelev, N. L., Labib, S., Bourdon-Lacombe, J., Kuo, B., Buick, J. K., Lemieux, F., Williams, A., Halappanavar, S., Malik, A. I., Luijten, M., Aubrecht, J., Hyduke, D. R., Fornace, A. J., Jr, Swartz, C. D., Recio, L., and Yauk, C. L. Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol 45: 1-43, 2015. 

Bouhifd, M., Andersen, M. E., Baghdikian, C., Boekelheide, K., Crofton, K. M., Fornace, A. J., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P. D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J. D., Zhao, L., and Hartung, T. The human toxome project. ALTEX 32: 112-124, 2015. PMID: 25742299

Suman, S., Kumar, S., Moon, B. H., Strawn, S. J., Thakor, H., Fan, Z., Shay, J. W., Fornace, A. J., Jr, and Datta, K. Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice. Int. J. Radiat. Oncol. Biol. Phys. 2015. PMID: 26725728 

Williams, A., Buick, J. K., Moffat, I., Swartz, C. D., Recio, L., Hyduke, D. R., Li, H. H., Fornace, A. J., Aubrecht, J., and Yauk, C. L. A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data Brief 5: 77-83, 2015. PMID: 26425668 PMCID: PMC4564388 


Datta, K., Suman, S., Shay, J. W., and Fornace, A. J., Jr. Developing omics-based approaches for short- and long-term space radiation risk assessment. The Health Risks of Extraterrestrial Environments (THREE), 2014.

Mak, T. D., Tyburski, J. B., Krausz, K. W., Kalinich, J. F., Gonzalez, F. J., and Fornace, A. J Jr. Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics, Dec 2014.

Goudarzi, M., Weber, W. M., Mak, T. D., Chung, J., Doyle-Eisele, M., Melo, D. R., Brenner, D. J., Guilmette, R. A., and Fornace, A. J. Jr. Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, Cesium-137, using a shotgun LC-MS approach. J Proteome Res 2014. PMCID: PMC4286155 

Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. Circadian Control of Fatty Acid Elongation by SIRT1-mediated Deacetylation of Acetyl-CoA Synthetase 1. J Biol Chem. 2014 Jan 14.  

Paglia G, Williams JP, Menikarachchi L, Thompson JW, Tyldesley-Worster R, Halldórsson S, Rolfsson O, Moseley A, Grant D, Langridge J, Palsson BO, Astarita G. Ion Mobility Derived Collision Cross Sections to Support Metabolomics Applications. Anal Chem. 2014 Mar 28. 

Astarita G, McKenzie JH, Wang B, Strassburg K, Doneanu A, Johnson J, Baker A, Hankemeier T, Murphy J, Vreeken RJ, Langridge J, Kang JX. A Protective Lipidomic Biosignature Associated with a Balanced Omega-6/Omega-3 Ratio in fat-1 Transgenic Mice. PLoS One. 2014 Apr 23;9(4).

Astarita G, Kendall AC, Dennis EA, Nicolaou A. Targeted lipidomics strategies for oxygenated metabolites of polyunsaturated fatty acids. Biochim Biophys Acta. 2014 Dec 5. pii: S1388-1981(14)00251-0. doi: 10.1016/j.bbalip.2014.11.012.Review. 

Paglia G, Angel P, Williams JP, Richardson K, Olivos HJ, Thompson JW, Menikarachchi L, Lai S, Walsh C, Moseley A, Plumb RS, Grant DF, Palsson BO, Langridge J, Geromanos S, Astarita G. Ion Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification. Anal Chem. 2014 Dec 29.

Datta K, Suman S, Fornace AJ Jr. Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine. Int J Biochem Cell Biol. 2014 Dec;57:167-76.

Suman S, Moon BH, Thakor H, Fornace AJ Jr, Datta K. Wip1 Abrogation Decreases Intestinal Tumor Frequency in APCMin/+ Mice Irrespective of Radiation Quality. Radiat Res. 2014 Aug 12.

Laiakis EC, Strassburg K, Bogumil R, Lai S, Vreeken RJ, Hankemeier T, Langridge J, Plumb RS, Fornace AJ Jr, Astarita G. J Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation. Proteome Res. 2014 Aug 15.

Goudarzi M, Mak TD, Chen C, Smilenov LB, Brenner DJ, Fornace AJ. The effect of low dose rate on metabolomic response to radiation in mice.  Radiat Environ Biophys. 2014 Jul 22.

Tong M, McHardy I, Ruegger P, Goudarzi M, Kashyap PC, Haritunians T, Li X, Graeber TG, Schwager E, Huttenhower C, Fornace AJ Jr, Sonnenburg JL, McGovern DP, Borneman J, Braun J. Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism.  ISME J. 2014 Apr 29.

Li HH, Tyburski JB, Wang YW, Strawn S, Moon BH, Kallakury BV, Gonzalez FJ, Fornace AJ Jr. Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor α Protects Against Alcoholic Liver Disease. Alcohol Clin Exp Res. 2014 Jun;38(6):1520-1531.

Laiakis EC, Mak TD, Anizan S, Amundson SA, Barker CA, Wolden SL, Brenner DJ, Fornace AJ Jr. Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation.  Radiat Res. 2014 Apr;181(4):350-61.

Trani D, Nelson SA, Moon BH, Swedlow JJ, Williams EM, Strawn SJ, Appleton PL, Kallakury B, Näthke I, Fornace AJ Jr. High-energy particle-induced tumorigenesis throughout the gastrointestinal tract. Radiat Res. 2014 Feb;181(2):162-71. doi: 10.1667/RR13502.1.

Cheema AK, Suman S, Kaur P, Singh R, Fornace AJ Jr, Datta K. Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure. PLoS One. 2014 Jan 27;9(1):e87079.

Kafle A, Coy SL, Wong BM, Fornace AJ Jr, Glick JJ, Vouros P. Understanding Gas Phase Modifier Interactions in Rapid Analysis by Differential Mobility-Tandem Mass Spectrometry. J. Am Soc Mass Spectrom. 2014 Jan 23.

Goudarzi M, Weber W, Mak TD, Chung J, Doyle-Eisele M, Melo D, Brenner DJ, Guilmette RA, Fornace AJ. Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res. 2014 Jan;181(1):54-64.

Mak TD, Laiakis EC, Goudarzi M, Fornace AJ Jr. MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data. Anal Chem. 2014 Jan 7;86(1):506-13.

Lee, J. S., Park, J. R., Kwon, O. S., Kim, H., Fornace, A. J., Jr, and Cha, H. J. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci 73: 125-134, 2014. PMID: 24126074  

Cheema, A. K., Suman, S., Kaur, P., Singh, R., Fornace, A. J. Jr., and Datta, K. Long-Term Differential Changes in Mouse Intestinal Metabolomics after gamma and Heavy Ion Radiation Exposure. PLoS ONE 9: e87079, 2014. PMID: 24475228 PMCID: PMC3903607

Li, H. H., Tyburski, J. B., Wang, Y. W., Strawn, S., Moon, B. H., Kallakury, B. V., Gonzalez, F. J., and Fornace, A. J., Jr. Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor alpha Protects Against Alcoholic Liver Disease. Alcohol Clin Exp Res 2014. PMID: 24773203


Bellet MM, Nakahata Y, Boudjelal M, Watts E, Mossakowska DE, Edwards KA, Cervantes M, Astarita G, Loh C, Ellis JL, Vlasuk GP, Sassone-Corsi P. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A. 2013 Jan 22.

Astarita G and Langridge J. An Emerging Role for Metabolomics in Nutrition Science. J Nutrigenet Nutrigenomics 2013;6:179-198.

McHardy IH, Goudarzi M, Tong M, Ruegger PM, Schwager E, Weger JR, Graeber TG, Sonnenburg JL, Horvath S, Huttenhower C, McGovern DP, Fornace AJ Jr, Borneman J, Braun. Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships.  J. Microbiome. 2013 Jun 5;1(1):17. doi: 10.1186/2049-2618-1-17.

Datta, K., Suman, S., Kallakury, B. V., and Fornace, A. J., Jr. Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater beta-Catenin Activation than gamma Radiation in APC(Min/+) Mice. PLoS ONE 8: e59295, 2013.

Hyduke, D. R., Laiakis, E. C., Li, H. H., and Fornace, A. J., Jr. Identifying radiation exposure biomarkers from mouse blood transcriptome. Int. J. Bioinformatics Research and Applications 9: 365-385, 2013.

Laiakis, C., Bogumil, R., Roehring, C., Daxboeck, M., Lai, S., Breit, M., Shockcor, J., Cohen, S., Langridge, J., Fornace, A. J., Jr, and Astarita, G. Targeted Metabolomics Using the UPLC/MS-based Absolute IDQ p180 Kit. Waters Application Note Library Number: APNT134720655: 1-8, 2013 

Coy, S. L., Krylov, E. V., Nazarov, E. G., Fornace, A. J., Jr, and Kidd, R. D. Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics. Int J Ion Mobil Spectrom 16: 217-227, 2013. PMID: 23914140 PMCID: PMC3728710

Goudarzi, M., Koga, T., Khozoie, C., Mac, T. D., Kang, B. H., Fornace, A. J., Jr, and Peters, J. M. PPARbeta/delta modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Toxicology 311: 87-98, 2013. PMID: 23851158

Suman, S., Rodriguez, O. C., Winters, T. A., Fornace, A. J., Jr, Albanese, C., and Datta, K. Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production. Aging 5: 607-622, 2013. PMID: 23928451 

Suman, S., Datta, K., Chakraborty, K., Kulkarni, S. S., Doiron, K., Fornace, A. J., Jr, Sree Kumar, K., Hauer-Jensen, M., and Ghosh, S. P. Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol 60: 488-496, 2013. PMID: 23941772

Li, H. H., Doiron, K., Patterson, A. D., Gonzalez, F. J., and Fornace, A. J., Jr. Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease. J Transl Med 11: 266, 2013. PMID: 24152801

Salvador, J. M., J. D. Brown-Clay, and J. Fornace, AJ. Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis. In D. A. Liebermann, and B. Hoffman (eds.), Gadd45 Stress Sensor Genes. Springer Science + Business Media. 1-19, 2013.  Also in Adv. Exp. Med. Biol. 793: 1-19, 2013. PMID: 24104470

Kleensang, A., Maertens, A., Rosenberg, M., Fitzpatrick, S., Lamb, J., Auerbach, S., Brennan, R., Crofton, K. M., Gordon, B., Fornace, A. J., Jr, Gaido, K., Gerhold, D., Haw, R., Henney, A., Ma’ayan, A., McBride, M., Monti, S., Ochs, M. F., Pandey, A., Sharan, R., Stierum, R., Tugendreich, S., Willett, C., Wittwehr, C., Xia, J., Patton, G. W., Arvidson, K., Bouhifd, M., Hogberg, H. T., Luechtefeld, T., Smirnova, L., Zhao, L., Adeleye, Y., Kanehisa, M., Carmichael, P., Andersen, M. E., and Hartung, T. t4 Workshop Report: Pathways of Toxicity. ALTEX 2013. PMID: 24127042


Suman, S., Fornace, A. J. Jr., and Datta, K. Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development, in Colorectal Cancer - From Prevention to Patient Care, Rajunor Ettarh (Ed.), 277-300, 2012; ISBN: 978-953-51-0028-7, InTech, Available from here

Lowe, J., Cha, H., Lee, M. O., Mazur, S. J., Appella, E., and Fornace, A. J. Jr. Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci 17: 1480-1498, 2012.

Datta, K., Suman, S., Trani, D., Doiron, K., Rotolo, J. A., Kallakury, B. V., Kolesnick, R., Cole, M. F., and Fornace, A. J., Jr. Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int. J. Radiat. Biol. 88: 213-222, 2012.

Suman, S., Maniar, M., Fornace, A. J., Jr., and Datta, K. Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol 7: 6, 2012.

Suman, S., Johnson, M. D., and Fornace, A. J., Jr. Exposure to Ionizing Radiation Causes Long-Term Increase in Serum Estradiol and Activation of PI3K-Akt Signaling Pathway in Mouse Mammary Gland. Int J Radiat Oncol Biol Phys 84: 500-507, 2012.

Trani, D., Moon, B. H., Kallakury, B., Hartmann, D. P., Datta, K., and Fornace, A. J., Jr. Sex-dependent Differences in Intestinal Tumorigenesis Induced in Apc1638N/+ Mice by Exposure to Gamma Rays. Int. J. Radiat. Oncol. Biol. Phys. in press: 2012.

Suman, S., Datta, K., Trani, D., Laiakis, E. C., Strawn, S. J., and Fornace, A. J. J. Relative biological effectiveness of (12)C and (28)Si radiation in C57BL/6J mice. Radiat. Environ. Biophys. 51: 303-309, 2012.

Datta, K., Suman, S., Kallakury, B. V., and Fornace, A. J., Jr. Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS ONE 7: e42224, 2012.

Suman, S., Datta, K., Doiron, K., Ren, C., Kumar, R., Taft, D. R., Fornace, A. J., Jr, and Maniar, M. Radioprotective Effects of ON 01210.Na upon Oral Administration. J. Radiat. Res. 53: 368-376, 2012.

Datta, K., Hyduke, D. R., Suman, S., Moon, B. H., Johnson, M. D., and Fornace, A. J. J. Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland. Radiat Oncol 7: 205, 2012.

Brown-Clay, J. D., and A. J. Fornace, Jr. Gadd45. In S. Choi (ed.), Encyclopedia of Signaling Molecules. Springer, p. 741-749, 2012 (ISBN 978-1-4419-0460-7).

Laiakis, E. C., Hyduke, D. R., and Fornace, A. J. Comparison of Mouse Urinary Metabolic Profiles after Exposure to the Inflammatory Stressors gamma Radiation and Lipopolysaccharide. Radiat. Res. 177: 187-199, 2012. 


Hyduke, D. R., Amundson, S. A. and Fornace, A. J., Jr. Complexity of Stress Signaling. In R. A. Bradshaw, and E. A. Dennis (eds.), Regulation of Organelle and Cell Compartment Signaling: Cell Signaling Collection. Academic Press, 2011.

Lee, M. O., Lee, H. J., Kim, M. A., Kim, E. K., Lee, J. H., Heo, J. H., Lee, S. H., Cho, S. H., Fornace, A. J. J., Jeong, H. C., and Cha, H. J. p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation. J Thorac Oncol 6: 423-431, 2011.

Sheikh, K. D., Khanna, S., Byers, S. W., Fornace, A. J., and Cheema, A. K. Small Molecule Metabolite Extraction Strategy for Improving LC/MS Detection of Cancer Cell Metabolome. J Biomol Tech 22: 1-4, 2011.

Coy, J., Cheema, A., Tyburski, J. B., Laiakis, E. C., Collins, S. P., and Fornace, A. J., Jr. Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol 87): 802-23, 2011.

Laiakis E.C., Hyduke D.R., and Fornace A.J., Jr. Comparison of Mouse Urinary Metabolic Profiles after Exposure to the Inflammatory Stressors γ Radiation and Lipopolysaccharide. Radiat Res 2011.

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Idle, J. R., Fornace, A. J., and Gonzalez, F. J. UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res 10: 4120-4133, 2011.

Lee, J. S., Lee, H. J., Moon, B. H., Song, S. H., Lee, M. O., Shim, S. H., Kim, H. S., Lee, M. C., Kwon, J. T., Fornace, A. J. Jr., Kim, S. U., and Cha, H. J. Generation of Cancerous Neural Stem Cells Forming Glial Tumor by Oncogenic Stimulation. Stem Cell Rev 2011.


Trani, D., Datta, K., Doiron, K., Kallakury, B., and Fornace, A. J., Jr. Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys 49: 389-396, 2010.

Cha, Y., Moon, B. H., Lee, M. O., Ahn, H. J., Lee, H. J., Lee, K. A., Fornace, Jr, A. J., Kim, K. S., Cha, H. J., and Park, K. S. Zap70 Functions to Maintain Stemness of Mouse Embryonic Stem Cells Negatively Regulating Jak1/Stat3/c-Myc Signaling. Stem Cells 28: 1476-1486, 2010.

Laiakis, E. C., Morris, G. A., Fornace, A. J., Jr, and Howie, S. R. Metabolomic analysis in severe childhood pneumonia in the gambia, west Africa: findings from a pilot study. PLoS One 5: 2010.

Kim, J. J., Lee, J. S., Moon, B. H., Lee, M. O., Song, S. H., Li, H., Fornace, A. J., and Cha, H. J. Wip1-expressing feeder cells retain pluripotency of co-cultured mouse embryonic stem cells under leukemia inhibitory factor-deprivated condition. Arch Pharm Res 33: 1253-1260, 2010.

Romanov, V. S., Abramova, M. V., Svetlikova, S. B., Bykova, T. V., Zubova, S. G., Aksenov, N. D., Fornace, A. J. J., Pospelova, T. V., and Pospelov, V. A. p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate. Cell Cycle 9: 3945-3955, 2010.

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Li, H., Idle, J. R., Fornace, A., and Gonzalez, F. J. Identification of Noninvasive Biomarkers for Alcohol-Induced Liver Disease Using Urinary Metabolomics and the Ppara-null Mouse. J Proteome Res 9: 4176-4188, 2010.

Tront, J. S., Huang, Y., Fornace, A., Jr, Hoffman, B., and Liebermann, D. A. Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res. 70: 9671-9681, 2010.

Hyduke, D. R., S. A. Amundson, and A. J. Fornace, Jr. Complexity of Stress Signaling. In R. A. Bradshaw, and E. A. Dennis (eds.), Handbook of cell signaling. Academic press, Amsterdam; San Diego, Calif.; p. 2107-2125, 2010

Goodsaid, F. M., Amur, S., Aubrecht, J., Burczynski, M. E., Carl, K., Catalano, J., Charlab, R., Close, S., Cornu-Artis, C., Essioux, L., Fornace, A. J. Jr., Hinman, L., Hong, H., Hunt, I., Jacobson-Kram, D., Jawaid, A., Laurie, D., Lesko, L., Li, H. H., Lindpaintner, K., Mayne, J., Morrow, P., Papaluca-Amati, M., Robison, T. W., Roth, J., Schuppe-Koistinen, I., Shi, L., Spleiss, O., Tong, W., Truter, S. L., Vonderscher, J., Westelinck, A., Zhang, L., and Zineh, I. Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact. Nat Rev Drug Discov 9: 435-445, 2010.

Lynch, A. M., Sasaki, J. C., Elespuru, R., Jacobson-Kram, D., Thybaud, V., De Boeck, M., Aardema, M. J., Aubrecht, J., Benz, R. D., Dertinger, S. D., Douglas, G. R., White, P. A., Escobar, P. A., Fornace, A. J., Honma, M., Naven, R. T., Rusling, J. F., Schiestl, R. H., Walmsley, R. M., Yamamura, E., van Benthem, J., and Kim, J. H. New and emerging technologies for genetic toxicity testing. Environ Mol Mutagen 52: 205-23, 2010.

Lowe, J. M., Cha, H., Yang, Q., and Fornace, Jr, A. J. Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase. J Biol Chem 285: 5249-5257, 2010.

Coy, S. L., Krylov, E. V., Schneider, B. B., Covey, T. R., Brenner, D. J., Tyburski, J. B., Patterson, A. D., Krausz, K. W., Fornace, A. J., and Nazarov, E. G. Detection of Radiation-Exposure Biomarkers by Differential Mobility Prefiltered Mass Spectrometry (DMS-MS). Int J Mass Spectrom 291: 108-117, 2010.

Cha, H., Lowe, J. M., Lee, J. S., Belova, G. I., Bulavin, D. V., and Fornace, Jr, A. J. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res 70: 4112-4122, 2010.


Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavik, J., Fornace, A. J. J., Gonzalez, F. J., and Idle, J. R. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 172: 42-57, 2009.

Ellinger-Ziegelbauer, H., Fostel, J. M., Aruga, C., Bauer, D., Boitier, E., Deng, S., Dickinson, D., Le Fevre, A. C., Fornace, A. J. J., Grenet, O., Gu, Y., Hoflack, J. C., Shiiyama, M., Smith, R., Snyder, R. D., Spire, C., Tanaka, G., and Aubrecht, J. Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. Toxicol Sci 110: 341-352, 2009.

Park, H. U., Suy, S., Danner, M., Dailey, V., Zhang, Y., Li, H., Hyduke, D. R., Collins, B. T., Gagnon, G., Kallakury, B., Kumar, D., Brown, M. L., Fornace, A., Dritschilo, A., and Collins, S. P. AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther 8: 733-741, 2009.

Lee, J. S., Lee, M. O., Moon, B. H., Shim, S. H., Fornace, Jr, A. J., and Cha, H. J. Senescent Growth Arrest in Mesenchymal Stem Cells is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways. Stem Cells 27: 1963-1975, 2009.

Demidov, O. N., Cha, H., Bulavin, D. V., and Fornace, A.J., Jr. Wip1, an Oncogene Targeting Tumor Suppressors Expressed in Intestinal Stem Cells. Current Colorectal Cancer Reports 5: 197-202, 2009.


Patterson, A., Li, H.H., Eichler, G., Krausz, K., Weinstein, J., Fornace, A. J. Jr., Gonzalez, F., and Idle, J. UPLC-ESI-TOFMS-Based Metabolomics and GEDI Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to Ionizing Radiation. Analytical Chemistry 80: 665-74, 2008.

Amundson, S. A., Do, K. T., Vinikoor, L. C., Lee, R. A., Koch-Paiz, C. A., Ahn, J., Reimers, M., Chen, Y., Scudiero, D. A., Weinstein, J. N., Trent, J. M., Bittner, M. L., Meltzer, P. S., and Fornace, A. J. Jr. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the NCI Anti-Cancer Drug Screen. Cancer Res. 68: 415-24, 2008.

Lu, X., Yang, C., Hill, R., Yin, C., Hollander, M. C., Fornace, Jr, A. J., and Van Dyke, T. Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 68: 3579-3583, 2008.

Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavik, J., Fornace, Jr, A. J., Gonzalez, F. J., and Idle, J. R. Radiation metabolomics: identification of minimally invasive urine biomarkers for gamma radiation exposure in mice. Radiat Res 170: 1–14, 2008.


Cha, H., Wang, X., Li, H. H., and Fornace, A. J. Jr. A functional role for p38 MAP kinase in modulating mitotic transit in the absence of stress. J. Biol. Chem. 282: 22984-92, 2007.

Ku, W. W., Aubrecht, J., Mauthe, R. J., Schiestl, R. H., and Fornace, A. J. Jr. Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment. Toxicol. Sci.99: 20-5, 2007.

Li HH, Aubrecht J, Fornace AJ Jr. Toxicogenomics: Overview and potential applications for the study of non-covalent DNA interacting chemicals.Mutat Res. 2007 Apr 21;99:20-25 (Review)

Jirmanova L, Jankovic D, Fornace AJ Jr, Ashwell JD. Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.J Immunol. 2007 Apr 1;178(7):4153-8.

Demidov, O. N., Kek, C., Shreeram, S., Timofeev, O., Fornace, A. J., Appella, E., and Bulavin, D. V. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene 26: 2502-6, 2007.


Bishop, A. J., Kosaras, B., Hollander, M. C., Fornace, Jr, A. J., Sidman, R. L., and Schiestl, R. H. p21 controls patterning but not homologous recombination in RPE development. DNA Repair (Amst) 5: 111-120, 2006.

Patterson, A., Hildesheim, J., Fornace, A. J. Jr., and Hollander, M. C. Neural Tube Development Requires the Cooperation of p53 and Gadd45a Associated Pathways. Birth Defects Research Part A: Clinical and Molecular Teratology in press, 2006.

Patterson, A. D., Hollander, M. C., Miller, G. F., and Fornace, A. J. Jr. Gadd34 Requirement for Normal Hemoglobin Synthesis, Mol. Cell. Biol. 187: 1644-1653, 2006.

Dudgeon, C., Kek, C., Demidov, O. N., Saito, S., Fernandes, K., Diot, A., Bourdon, J. C., Lane, D. P., Appella, E., Fornace, Jr, A. J., and Bulavin, D. V. Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Res 66: 2928-2936, 2006.

Cai, Q., Dmitrieva, N. I., Ferraris1, J.. D., Michea, L. F., Salvador, J. M., Hollander, M. C., Fornace, A. J., Jr., Fenton, R., and Burg, M. B. Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Am. J. Physiol. Renal Physiol. 291:F341-9, 2006.

Abramova, M. V., Pospelova, T. V., Nikulenkov, F. P., Hollander, M. C., Fornace, A. J., Pospelov, V. A. G1/S arrest induced by HDAC inhibitor sodium butyrate in E1A+Ras transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J. Biol. Chem. 281:21040-51, 2006.

Shreeram, S., Demidov, O. N., Hee, W. K., Yamaguchi, H., Onishi, N., Kek, C., Timofeev, O. N., Dudgeon, C., Fornace, Jr, A. J., Anderson, C. W., Minami, Y., Appella, E., and Bulavin, D. V. Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways. Mol Cell 23: 757-764, 2006.

Liebe, B., Petukhova, G., Barchi, M., Bellani, M., Braselmann, H., Nakano, T., Pandita, T. K., Jasin, M., Fornace, A., Meistrich, M. L., Baarends, W. M., Schimenti, J., de Lange, T., Keeney, S., Camerini-Otero, R. D., and Scherthan, H. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res 312:3768-81, 2006.

Shreeram, S., Hee, W.K., Demidov, O.N., Kek, C., Yamaguchi, H., Fornace, A.J., Anderson, C.W., Appella, E., and Bulavin, D.V, Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J. Exp. Med. 203: 2793-9, 2006.

Demidov, O. N., Kek, C., Shreeram, S., Timofeev, O., Fornace, A. J., Appella, E., and Bulavin, D. V. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene in press 2006.

Abramova, M. V., Pospelova, T. V., Nikulenkov, F. P., Hollander, C. M., Fornace, A. J., Jr, and Pospelov, V. A. G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J. Biol. Chem. 281: 21040-21051, 2006. PMID: 16717102


Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg. E. C., R. Linnoila, I., and Fornace, A. J. Jr. Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A 102: 13200-13205, 2005.

Pal, R., Datta, A., Fornace, Jr, A. J., Bittner, M. L., and Dougherty, E. R. Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS. Bioinformatics 21: 1542-1549, 2005.

Hildesheim, J., Salvador, J. M., Hollander, M. C., and Fornace, Jr, A. J. Casein Kinase 2- and Protein Kinase A-regulated Adenomatous Polyposis Coli and (beta}-Catenin Cellular Localization Is Dependent on p38 MAPK. J Biol Chem 280: 17221-17226, 2005.

Amundson, S. A, Do, K. T. Vinikoor, L., Koch-Paiz, C. A., Bittner, M.L., Trent, J. M., Meltzer, P., and Fornace, A. J. Jr. Stress-specific signatures: Expression profiling of p53 wild-type and null human cells. Oncogene 24: 4572-9, 2005.

Salvador, J. M., Mittelstadt, P. R., Guszczynski, T., Copeland, T. D., Yamaguchi, H., Appella, E., Fornace, Jr, A. J., and Ashwell, J. D. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 6: 390-395, 2005. Also see News and Views: Rudd, C. E. MAPK p38: alternative and nonstressful in T cells. Nat Immunol 6: 368-370, 2005.

Salvador, J. M., Mittelstadt, P. R., Belova, G. I., Fornace, Jr, A. J., and Ashwell, J. D. The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway. Nat Immunol 6: 396-402, 2005.

Hollander, M. C., Patterson, A. D., Salvador, J. M., Anver, M. R., Hunger, S. P., and Fornace, A. J. Gadd45a acts as a modifier locus for lymphoblastic lymphoma. Leukemia 19: 847-850, 2005.

Roper, J. M., Gehen, S. C., Staversky, R. J., Hollander, M. C., Fornace, Jr, A. J., and O'Reilly, M. A. Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol 288: L663-71, 2005.

Hollander, M. C., Philburn, R. T., Patterson, A. D., Wyatt, M. A., and Fornace, Jr, A. J. Genomic Instability in Gadd45a(-/-) Cells is Coupled with S-Phase Checkpoint Defects. Cell Cycle 4: 704-709, 2005.

Khaled, A. R., Bulavin, D. V., Kittipatarin, C., Li, W. Q., Alvarez, M., Kim, K., Young, H. A., Fornace, A. J., and Durum, S. K. Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol 169: 755-763, 2005.

Gupta, M., Gupta, S. K., Balliet, A. G., Hollander, M. C., Fornace, A. J., Hoffman, B., and Liebermann, D. A. Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene 2005.

Jirmanova, L., Bulavin, D. V., and Fornace, A. J. Jr. Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle, in press, 2005.

Belova, G. I., Demidov, O. N., Fornace, A. J. Jr., and Bulavin, D. V. Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis. Cancer Biology and Therapy in press, 2005.

Denko, N. C. and Fornace, A. J., Jr. (Editors) Editorial comment: Mutation Research Special Issue on stress responses. Mutation Res. 569: 1-2, 2005.(Review)

Mittelstadt, P. R., Salvador, J. M., Fornace, A. J., Jr., and Ashwell, J. D. Activating p38 MAPK: new tricks for an old kinase. Cell Cycle 4: 1189-1192, 2005.(Review)

Hildesheim, J. and Fornace, A. J., Jr.  Gadd45a. UCSD-Nature Molecule Pages, 2005. (doi:10.1038/mp.a001020.01)


Koch-Paiz, C. A., Amundson, S. A., Bittner, M., Meltzer, P., and Fornace, A.J., Jr.Functional genomics of UV radiation responses in human cells. Mutation Res. 549: 65-78, 2004.

Bulavin, D. V., Phillips, C., Nannenga, B., Timofeev, O., Donehower, L. A., Anderson, C. W., Appella, E., and Fornace, A. J. Jr.Inactivation of the Wip1 Phosphatase Inhibits Mammary Tumorigenesis through p38 MAPK-mediated Activation of the Ink4a/Arf Pathway. Nature Genetics 36: 343-350, 2004.

Hildesheim, J., Awaad, R. T., and Fornace, A.J. Jr. p38 MAP kinase inhibitor protects the epidermis against the acute damaging effects of UV irradiation by blocking apoptosis and inflammatory responses. J. Invest. Derm. 122: 497-502, 2004.

Hildesheim, J., Belova, G. I., Tyner, S. D., Zhou, X., Vardanian, L., and Fornace, Jr, A. J. Gadd45a regulates matrix metalloproteinases by suppressing DNp63alpha and ?catenin via p38 MAP kinase and APC complex activation. Oncogene 23: 1829-1837, 2004.

Bulavin, D. B. and Fornace, A. J., Jr. p38 MAP kinase's emerging role as a tumor suppressor. Advances in Cancer Research, Elsevier Publishers, (eds. Klein and Vande Woude) Volume 92: in press, 2004.(Review)

Hildesheim, J., and A. J. Fornace, Jr. The dark side of light: The damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis. DNA Repair 3: 567-580, 2004. (Review)

Amundson, S. A., and A. J. J. Fornace. Microarray approaches for analysis of cell cycle regulatory genes. Methods Mol Biol 241: 125-141, 2004. (Review)

Rockett, J. C., Burczynski, M. E., Fornace, A. J., Jr., Herrmann, P.C., Krawetz, S. A., and Dix, D. J. Surrogate Tissue Analysis: Monitoring Toxicant Exposure And Health Status Of Inaccessible Tissues Through The Analysis Of Accessible Tissues And Cells. Toxocol. and Applied Pharmacol., 194: 189-199, 2004. (Review)

Wang, X., Wang, R. H., Li, W., Xu, X., Hollander, C., Fornace, A., and Deng, C.  Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability and neural tube closure.  J. Biol. Chem. 279: 29606-29614, 2004.

Amundson, S. A, Grace, M. B., McLeland, C. B., Epperly, M. W., Yeager, A., Zhan, Q., Greenberger, J. S. and Fornace, A. J., Jr. Human in vivo radiation-induced biomarkers:  gene expression changes in radiotherapy patients.  Cancer Res. 64:  6368-6371, 2004.


Jiang, F., P. Li, A. J. Fornace, Jr, S. V. Nicosia, and W. Bai. G2/M Arrest by 1,25 dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem 278: 48030-48040, 2003.

Saito, S, Yamaguchi, H., Higashimoto, Y., Chao, C, Xu, Y., Fornace, A.J. Jr., Appella, E., and Anderson, C.W. Phosphorylation Site Interdependence of Human p53 Posttranslational Modifications in Response to Stress. J. Biol. Chem. 278: 37536?7544, 2003.

Bishop, A. J., M. C. Hollander, B. Kosaras, R. L. Sidman, A. J. Fornace, Jr, and R. H. Schiestl. Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res 63: 5335-5343, 2003.

Yoo, J, Ghiassi, M., Jirmanova, L., Balliet, A.G., Hoffman, B., Fornace, A. J. Jr., Liebermann, D.A., Böttinger, E.P., and Roberts, A.B. TGF-b-induced apoptosis is mediated by Smad-dependent expression of GADD45B through p38 activation. J. Biol. Chem. 278: 43001-7, 2003.

Balliet, A. G., M. C. Hollander, A. J. Fornace, Jr, B. Hoffman, and D. A. Liebermann. Comparative Analysis of the Genetic Structure and Chromosomal Mapping of the Murine Gadd45g/CR6 Gene. DNA Cell Biol. 22: 457-468, 2003.

Amanullah, A., Azam, N., Balliet, A., Hollander, M.C., Hoffman, B., Fornace, A.J. Jr., and Liebermann, D.Cell signalling: Cell survival and a Gadd45-factor deficiency. Nature 424: 741, 2003.

Goloudina, A., Yamaguchi, H., Chervyakova, D. B., Appella, E, Fornace, A. J. Jr., and Bulavin, D. V. Regulation of human Cdc25A stability by serine 75 phosphorylation is not sufficient to activate a S-phase checkpoint. Cell Cycle 2: 473-8, 2003.

Commentary: Neely, K.E. and Piwnica-Worms, H. Cdc25A regulation, To destroy or not to destroy?is that the only question? Cell Cycle 2: 455-7, 2003.

Bulavin, D. V., Demidenko, Z. N., Moody, S. A., Appella, E., and Fornace, A. J. Jr. Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in the pre-midblastula embryos. Cell Cycle 2: 263-266, 2003. Commentary: Manke, I. A, & Yaffe, M. B., Chk’n Out in Mitosis. Cell Cycle 2: 236-237, 2003.

Bulavin, D. V., Higashimoto, Y., Demidenko, Z. N., Meek, S., Graves, P., Phillips, C., Zhao, H., Moody, S. A., Appella, E., and Fornace, A. J. Jr. Dual Phosphorylation Controls Cdc25 Phosphatases and Mitotic Entry. Nature Cell Biology 5: 545-551, 2003.

Hollander, M.C., Poola-Kella, S., and Fornace, A. J. Jr. Gadd34 functional domains involved in growth suppression and apoptosis. Oncogene 22: 3827-3832, 2003.

Bulavin, D. V., Kovalsky, O., Hollander, M. C., and Fornace, A. J. Jr. Abrogation of oncogenic H-ras-induced cell-cycle arrest and p38 MAPK activation by disruption of Gadd45a. Mol. Cell. Biol. 23: 3859-3871, 2003.

Amundson, S. A., Lee, A., Koch-Paiz, C. A., Bittner, M.L., Meltzer, P., Trent, J. M., and Fornace, A. J. Jr. Differential responses of stress genes to low dose-rate g irradiation.Molecular Cancer Res. 1: 445-452, 2003.

Amundson, SA and Fornace, A.J., Jr. Complexity of stress signaling and responses, in Handbook of Cell Signaling (Karin, M, et al. ed.) Academic Press, San Diego, CA, 3: 179-184, 2003. (Review)

Amundson, S.A. and Fornace, A.J., Jr. Monitoring human radiation exposure by gene expression profiling: Possibilities and Pitfalls. Health Physics, 85: 36-42, 2003. (Review)

Amundson, S.A., Bittner, M., and Fornace, A. J., Jr. Functional genomics as a window on radiation stress signaling. Oncogene 22: 5828-5833, 2003. (Review)


Hildesheim, J., Bulavin, D., Anver, M. R., Alvord, W. G., Hollander, M. C., Vardanian, L., and Fornace, Jr, A. Gadd45a protects against UV irradiation-induced skin tumors and promotes apoptosis and stress signaling via MAP kinases and p53. Cancer Res. 62: 7305-7315, 2002.

Fan, F., Jin, S., Amundson, S. A., Tong, T., Fan, W., Zhao, H., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., Fornace, Jr, A. J., Rajasekaran, B., and Zhan, Q.ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21: 7488-7496, 2002.

Morinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A., Montagna, C., Feldman, G. M., Nishikomori, R., and O'Shea, J. J. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A 99: 12281-12286, 2002.

Bulavin, D. V., Demidov, O. N., Saito, S., Kauraniemi, P., Phillips, C., Amundson, S. A., Ambrosino, C., Sauter, G., Nebreda, A. R., Anderson, C. W., Kallioniemi, A., Fornace, Jr, A. J., and Appella, E. Amplification of the Wip1 phosphatase gene in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 31: 210-215, 2002.

Salvador, J.M., Hollander, M.C., Nguyen, A.T., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., and Fornace, A.J., Jr. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 499-508, 2002.

Amundson,, S.A., Patterson, A., Do, K.T., and Fornace, A.J., Jr. A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes. Cancer Biology and Therapy 1: 145-149, 2002.

Tran, H., Brunet, A., Grenier, J. M., Datta, S. R., Fornace, A. J., Jr, DiStefano, P. S., Chiang, L. W., and Greenberg, M. E. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534, 2002.

Dmitrieva, N.I., Bulavin, D.V., Fornace, A.J., Jr., and Burg, M.B. Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc. Natl. Acad. Sci. USA 99: 184, 189, 2002.

Amundson, S. A., K. T. Do, P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr. Stress-gene induction by low-dose gamma-irradiation. Military Med. 167: 13-15, 2002. (Review)

Bulavin, D, Amundson, S.A., and Fornace, A.J., Jr. p38 and Chk1 kinases: different conductors for the G2/M checkpoint symphony. Current Opinion in Genetics and Development, 12: 92-97, 2002. (Review)

Smith, M.L., and Fornace, A.J., Jr. Commentary: Chemotherapeutic Targeting of p53. Cancer Biology & Therapy 1: 56-57, 2002. (Review)

Hildesheim, J., and Fornace, Jr, A. J. Gadd45a: An Elusive Yet Attractive Candidate Gene in Pancreatic Cancer: Commentary re: K. Yamasawa et al., Clinicopathological Significance of Abnormalities in Gadd45 Expression and Its Relationship to p53 in Human Pancreatic Cancer. Clin. Cancer Res., 8: 2563-2569, 2002. (Review)Clin Cancer Res 8: 2475-2479, 2002. (Review)

Carrier, F., and Fornace, A.J., Jr. Ataxia-Telangiectasia Syndrome. In Encyclopedia of Cancer, J. R. Bertino (ed.), Academic Press, San Diego, CA., in press, 2002. (Review)

Amundson, SA and Fornace, A.J., Jr. Microarray approaches for analysis of tumor suppressor gene function, in Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications (El-Deiry, WS, ed.) Humana Press, Totowa, NJ., in press, 2002. (Review)

Hollander, M. C., and Fornace, A. J. Jr. Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 21: 6228-6233, 2002. (Review)


Kovalsky, O., F. D. Lung, P. P. Roller, and A. J. Fornace, Jr. Oligomerization of human Gadd45a protein. J. Biol. Chem. 276: 39330-39339, 2001.

Bulavin, D. V., Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur, O. Potapova, E. Appella, and A. J. Fornace, Jr. Initiation of a G2/M checkpoint after UV radiation requires p38 kinase. Nature 411: 102-107, 2001.

Hollander, M. C., O. Kovalsky, J. M. Salvador, K. E. Kim, A. D. Patterson, D. C. Hairnes, and A. J. Fornace, Jr. DMBA carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res. 61: 2487-2491, 2001.

Hollander, M. C., Sheikh, M. S., Yu, K., Zhan, Q., Iglesias, M., Woodworth, C., and Fornace, A.J., Jr. Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int. J. Oncology: Radiation Oncology Investigations: Basic & Clinical Res., 96: 22-31, 2001.

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr. Induction of gene expression as a monitor of radiation exposure. Radiation Res. 156: 657-61, 2001.

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr. Physiological function as regulation of large transcriptional programs: The cellular response to genotoxic stress. Comparative Biochemistry and Physiology 129: 703-710, 2001. (Review)

Amundson, S. A., P. Meltzer, J. Trent, M. Bittner, and A. J. Fornace, Jr. Biological indicators for the identification of radiation exposure in humans. Expert Review of Molecular Diagnostics 1: 89-97, 2001.

Amundson, S.A. and Fornace, A.J., Jr. Gene expression profiles for monitoring radiation exposure. Radiation Protection Dosimetry, 97: 11-16, 2001. (Review)

Amundson, S.A., Bittner, M. and Fornace, A.J., Jr. Microarray approaches for analysis of tumor suppressor gene function, in Tumor Suppressor Genes: Methods and Protocols (El-Deiry, W.S., ed.) Humana Press, Totowa, NJ, in press: 2001. (Review)

Fornace, A.J., Jr., Fuks, Z., Weichselbaum, R. R., and Milas, L. Radiation therapy. In The Molecular Basis of Cancer, Second Edition. Mendelsohn, J., Howley, P. M., Israel, M. A., and Liotta, L. A. (ed.), p.423-466, W. B. Saunders Co., Philadelphia., 2001. (Review)


Amundson, S.A., Myers, T.G., Scudiero, D., Kitada, S., Reed, J.C., and Fornace, A.J., Jr. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res. 60: 6101-6110, 2000.

Jin, S., H. Zhao, F. Fan, P. Blanck, W. Fan, A. B. Colchagie, A. J. Fornace, Jr, and Q. Zhan. BRCA1 activation of the GADD45 promoter. Oncogene 19: 4050-4057, 2000.

Koch-Paiz, C.A., Momenan, R., Amundson, S.A., Lamoreaux, E., and Fornace, A.J., Jr. Estimation of relative mRNA content by filter hybridization to a polyuridylic probe. Biotechniques 29: 706-714, 2000.

Amundson, S.A., K.T. Do, S. Shahab Bittner, M., Meltzer, P., Trent, J., and Fornace, A.J., Jr. Identification of potential mRNA markers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiation Res. 154: 342, 2000.

Zhao, H., Jin, S., Antinore, M.J., Lung, F.D.L., Fan, F., Blanck, P., Roller, P., Fornace, A.J., Jr., and Zhan, Q. The central region of Gadd45 is required for its interaction with p21/Waf1. Experimental Cell Res. 258: 92-100, 2000.

Jin, S., Antinore, M.J., Lung, F.D.T., Dong, X., Chao, H., Fan, F., Colchagie, A.B., Blanck, P., Roller, P.R., Fornace, A.J., Jr., and Zhan, Q. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J. Biol. Chem. 275: 16602-8, 2000.

Smith, M. L., Ford, J. M., Hollander, M. C., Bortnick, R. A., Amundson, S. A., Seo, Y. R., Deng, C. X., Hanawalt, P. C., and Fornace, Jr, A. J. p53-mediated DNA responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol. Cell. Biol. 20: 3705-3714, 2000.

Elizondo, G., Fernandez-Salguero, P., Sheikh, M. S., Kim, G. Y., Fornace, A. J., Lee, K. S., and Gonzalez, F. J. Altered Cell Cycle Control at the G(2)/M Phases in Aryl Hydrocarbon Receptor-Null Embryo Fibroblast. Mol Pharmacol 57: 1056-1063, 2000.

Meng, R.D., McDonald, E.R.,Sheikh, M.S., Fornace, A.J., Jr., El-Deiry, W.S. The TRAIL Decoy receptor TRUNDD (DcR2, TRAIL-R4I) is induced by Adenovirus-p53 overexpression and can delay TRAIL-, p53-, and Killer/DR5-dependent colon cancer apoptosis. Mol. Therapy 1: 130-144, 2000.

Sheikh, M.S., and Fornace, A.J., Jr. Death and decoy receptors and p53-mediated apoptosis. Leukemia 14: 1509-13, 2000. (Review)

Sheikh, M.S., Hollander, M.C. and Fornace, A.J., Jr. Role of Gadd45 in apoptosis. Biochemical Pharmacology 59: 43-45, 2000. (Review)

Sheikh, M.S., and Fornace, A.J., Jr. Role of p53 family members in apoptosis. J. Cell. Physiol. 182: 171-181, 2000. (Review)


Bulavin, D., Saito, S. I., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., and Fornace, Jr, A. J. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation which mediates activation of transcription and apoptosis in response to UV radiaton. EMBO J. 18: 6845-6854, 1999.

Graunke D.M., Fornace A.J., Jr., Pieper R.O. Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation. Nucleic Acids Res. 27: 3881-3890, 1999.

Hollander, M. C., Sheikh, M. S., Bulavin, D., Lundren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T., Kim, K., Tolosa, E., Ashwell, J. D., Rosenberg, M. D., Zhan, Q., Fernández-Salguero, P. M., Morgan, W. F., Deng, C. X., and Fornace, A.J., Jr. Genomic instability in Gadd45a-deficient mice. Nature Genetics 23: 176-184, 1999.

Adler, H. T., Chinery, R., Wu, D. Y., Kussick, S. J., Payne, J. M., Fornace, Jr, A. J., and Tkachuk, D. C. Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins. Mol. Cell. Biol. 19: 7050-7060, 1999.

Goldwasser, F., Bae, I., Pommier, Y., and Fornace, Jr, A. J. Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation. Anticancer Res. 19: 3167-3171, 1999.

Amundson, S. A., Do, K. T., and Fornace, A.J., Jr. Induction of Stress Genes by Low Doses of Gamma Rays. Radiat Res 152: 225-231, 1999.

Rishi, A. K., Sun, R. J., Gao, Y., Hsu, C. K., Gerald, T. M., Sheikh, M. S., Dawson, M. I., Reichert, U., Shroot, B., Fornace, Jr, A. J., Brewer, G., and Fontana, J. A. Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res 27: 3111-3119, 1999.

Sheikh, M.S., Huang, Y., Fernandez-Salas, E.A., El-Deiry, W.S., Friess, H., Amundson, S., Yin, J., Meltzer, S.J., Holbrook, N.J., and Fornace, A.J., Jr. The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene 18: 4153-4159, 1999.

Amundson, S.A., Bittner, M., Yidong, C., Trent, J., Meltzer, P., and Fornace, A.J., Jr. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18: 3666-3672, 1999.

Huang, Y., Sheikh, M.S., Fornace, A.J., Jr., and Holbrook, N.J. Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells. Oncogene 18: 3431-3439, 1999.

Sheikh, M. S., E. Fernandez-Salas, M. Yu, A. Husssain, J. D. Dinman, S. W. Peltz, Y. Huang, and A. J. Fornace, Jr. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1A121/SUI1). J. Biol. Chem. 274: 16487-16493, 1999.

Zhan, Q., Antinore, M., Wang, X.W., Carrier, F., Smith, M.L., Harris, C.C., and Fornace, A.J., Jr. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18: 2892-2900, 1999.

Wang, X. W., Q. Zhan, J. D. Coursen, M. Khan, H. U. Kontny, L. Liu, M. C. Hollander, P. M. O'Connor, A. J. Fornace, Jr, and C. C. Harris. Gadd45 induction of a G2-M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA 96: 3706-3711, 1999.

Carrier, F., Georgel, P.T., Pourquier, P., Blake, M., Kontny, H.U., Antinore, M.J., Gariboldi, M., Myers, T. G, Weinstein, J.N., Pommier, Y., and Fornace, A.J., Jr. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Molec. Cell. Biol. 19: 1673-1685, 1999.

Zhan, Q., Kontny, U., Iglesias, M., Alamo, I., Jr., Yu, K., Hollander, M.C., Woodworth, C.D., and Fornace, A.J., Jr. Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress. Oncogene 18: 297-304, 1999.

Bittner, M., Y. Chen, S. A. Amundson, J. Khan, A. J. Fornace, Jr, E. R. Dougherty, P. S. Meltzer, and J. M. Trent. Obtaining and evaluating gene expression profiles with cDNA microarrays. Proceedings of the International Conference on Genomics and Proteomics: Functional and Computational Aspects in press, 1999. (Review)

Sheikh, M.S., and Fornace, A.J., Jr. Regulation of translation initiation following stress. Oncogene 18: 6121-6128, 1999. (Review)

Fornace, A.J., Jr., Amundson, S.A., Bittner, M., Myers, T.G., Weinstein, J.N., Meltzer, P., and Trent, J. The complexity of radiation stress responses: analysis by informatics and functional genomics approaches. Gene Expression, 7: 387-400, 1999. (Review)


Sheikh, M.S., Antinore, M.J., Huang, Y, and Fornace, A.J., Jr. Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1. Oncogene 17: 2555-2564, 1998.

Amundson, S.A., Zhan, Q., Penn, L.Z. and Fornace, A.J., Jr. Myc suppresses induction of the growth arrest genes gadd34, gadd45 and gadd153 by DNA-damaging agents. Oncogene 17: 2149-2154, 1998.

Zaher, H., P. M. Fernandez-Salguero, J. Letterio, M. S. Sheikh, A. J. Fornace, Jr., A. B. Roberts, and F. J. Gonzalez. The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol. Pharmacol. 54: 313-321, 1998.

Smith, M.L., Bortnick, R.A., Sheikh, M.S., and Fornace, Jr., A.J. Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes. Exp Cell Res 242:235-243, 1998.

Carrier, F., Zhan, Q., Alamo, Jr, I., Hanaoka, F., and Fornace, Jr, A.J. Evidence for distinct kinase-mediated pathways in gadd gene responses. Biochemical Pharmacology 55: 853-861 1998.

Zhan, Q., Chen, I.T., and Fornace, Jr, A.J. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. Molec. Cell. Biol. 18: 2768-2778, 1998.

Sheikh, M.S., Burns, T.F., Huang, Y., Wu, G.S., Amundson, S., Brooks, K.S., Fornace, A.J., Jr. and El-Deiry, W.S. p53-dependent and independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and TNFa. Cancer Res. 58: 1593-1598, 1998.

Zhang, L., Q. Zhan, S. Zhan, F. Kashanchi, A. J. J. Fornace, P. Seth, and L. J. Helman. p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells. DNA Cell Biol. 17: 125-131, 1998.

Amundson, S. A., T. G. Myers, and A. J. Fornace, Jr. Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress. Oncogene 17: 3287-3300, 1998. (Review)

Smith, M.L., and Fornace, A.J., Jr. Correspondence re: J. S. DeFrank et al., p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res., 56: 5365-5368, 1996 [letter]. Cancer Res. 57: 5434-5436, 1997. (Review)

"Albert J. Fornace, Jr.: a member of The Editorial Academy of The International Journal of Oncology," Cover Legend. Int. J. Oncology 12: 3-4, 1998. (Review)


Sheikh, M.S., Carrier, F., Papathanasiou, M.A., Hollander, M.C., Zhan, Q., Yu, K. and Fornace Jr., A.J. Identification of several human homologs of hamster DNA damage inducible transcripts: cloning and characterization of novel UV inducible cDNA which codes for a putative RNA binding protein. J. Biological Chemistry 272: 26720-26726, 1997.

O’Connor, P.M., Jackman, J., Bae, I., Myers, T.G., Fan, S., Mutoh, M., Scudiero, D.A., Monks, A., Paull, K., Sausville, E.A., Weinstein, J.N., Friend, S., Fornace, Jr, A.J., and Kohn, K.W. Characterization of the p53 tumor suppressor pathway in cell lines of the NCI anticancer drug screen and correlations with the growth inhibitory potency of 123 anticancer agents. Cancer Res. 57: 4285-4300, 1997.

Sheikh, M.S., Carrier, F., Johnson, A.C., Ogdon, S.E. and Fornace Jr., A.J. Identification of an additional p53 regulatory site in the human epidermal growth factor receptor gene promoter. Oncogene 15: 1095-1101, 1997.

Marhin, W.W., Chen, S., Facchini, L.M., Fornace, Jr., A.J., and Penn, L.Z. Myc represses the growth arrest gene gadd45. Oncogene 14: 2825-2834, 1997.

Fan, S., Chang, J.K., Smith, M.L., Duba, D., Fornace, Jr, A.J., and O'Connor, P.M. Cells lacking CIP1/WAF1 genes exhibit enhanced sensitivity to cisplatin and nitrogen mustard, Oncogene 14: 2127-2136, 1997.

Hollander, M.C., Zhan, Q., Bae, I., Iglesias, M., Woodworth, C., and Fornace, Jr, A.J. Mammalian GADD34, a DNA damage-inducible gene associated with apoptosis. J. Biological Chemistry 272: 13731-13737, 1997.

Sheikh, M.S., Chen, Y.Q., Smith, M.L., and Fornace Jr., A.J. Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14: 1875-1882, 1997.

Smith, M. L., H. U. Kontny, R. Bortnick, and A. J. Fornace, Jr. The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. Exp. Cell Res. 230: 61-8, 1997.

Zhan, Q., Bae, I., Fornace, Jr, A.J., and Craig, R.W. Induction of Bcl-2 Family Member Mcl-1 as an Early Response to DNA Damage. Oncogene 14: 1031-9, 1997.

Weinstein, J.N., Myers, T.G., O’Connor, P.M., Friend, S.H., Fornace, A.J., Jr., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini, J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W., Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D. An information-intensive approach to the molecular pharmacology of cancer. Science 275: 343-349, 1997.

Fornace, A.J., Jr. Genotoxic stress responses associated with growth arrest and apoptosis, and the role of p53 in their regulation. In: Molecular Toxicology, utilitzation in accelerated drug discovery and chemical safety analysis, edited by Guttry, P., IBC Inc., Southborough, MA, p. 1-8, 1997. (Review)

Smith, M.L. and Fornace, A.J. Jr.: p53-mediated protective responses to UV irradiation. Proc. Natl. Acad. Sci. U S A 94: 12255-12257, 1997. (Review)


Goldwasser, F., Bae, I., Fornace, Jr, A.J., and Pommier, Y. Differential GADD45, p21CIP1/WAF1, MCL1, and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. Oncol. Res. 8: 317-323, 1996.

Chen, M.S., Fornace, A., Jr., and Laszlo, A. Characterization of an hsp70 related clone encoding a 33 kDa protein with homology to a protein which associates with polysomes. Biochim Biophys Acta 1297: 124-6, 1996.

Sheikh, M. S., M. Garcia, Q. Zhan, Y. Liu, and A. J. Fornace, Jr. Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Diff. 7: 1599-1607, 1996.

Zhan, Q., Alamo, Jr, I., Yu, K., Boise, L.H., O'Connor, P.M., and Fornace, Jr, A.J. The apoptosis-associated g-ray response of BCL-XL depends on normal p53 function. Oncogene 13: 2287-2293, 1996.

Smith, M.L., Kontny, H.U., Zhan, Q., Sreenath, A., O'Connor, P.M., and Fornace, A.J., Jr. Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to UV-irradiation or cisplatin. Oncogene 13: 2255-2263, 1996.

Zhan, Q., Fan, S., Smith, M.L., Bae, I., Yu, K., Alamo, I., Jr., O’Connor, P.M. and Fornace, A.J., Jr. Abrogation of p53 function affects gadd gene responses to DNA-base damaging agents and starvation. DNA and Cell Biology 15: 805-815, 1996.

Vairapandi, M., Balliet, A.G., Fornace, A.J., Jr., Hoffman, B., and Liebermann, D.A. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 12: 2579-2594, 1996.

Carrier, F., Bae, I., Smith, M.L., Ayers, D.M., and Fornace, A.J., Jr. Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a line containing a p53 mutation. Mutation Res. 352: 79-86, 1996.

Hollander, M.C., Alamo, I., and Fornace, A.J., Jr. A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product. Nucleic Acids Res. 24: 1589-1593, 1996.

Zhang, L., Kashanchi, F. Zhan, Q., Brady, J.N., Fornace, A.J., Seth, P., and Helman, L.J. Regulation of insulin-like growth factor II P3 promoter by p53: a potential mechanism for tumorigenesis. Cancer Res. 56: 1367-1373, 1996.

Bae, I., Smith, M.L., Zhan, Q., Friend, S.H., O’Connor, P.M., and Fornace, A.J., Jr. An abnormality in the p53 pathway following g-irradiation in many wild-type p53 human melanoma lines. Cancer Res. 56: 840-847, 1996.

Chen, I.T., Akamatsu, M., Smith, M.L., Roller, P.P., Fornace, A.J., Jr., and O’Connor, P.M. Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction. Oncogene 12:: 595-607, 1996.

Akamatsu, M., Chen, I-T., Fornace, A.J., Jr., O’Connor, P.M., and Roller, P.P. Conformational mapping of p21!af1/Cip1 protein, and cyclin dependent kinase -modulating effect of its peptide fragments. In: Peptides: Chemistry, Structure and Biology, edited by Kaumaya, P.T.P. and Hodges, R.S., Mayflower Scientific Ltd., p.370-371, 1996. (Review)

Smith, M.L. and Fornace, A.J. Jr.: The two faces of tumor suppressor p53-EDITORIAL. Amer. J. Pathology 148: 1019-1022, 1996. (Review)

Gorospe, M., Martindale, J.L., Sheikh, M.S., Fornace, A.J. Jr., and Holbrook, N.J.: Regulation of p21CIP1/WAF1 expression by cellular stress: p53-dependent and p53-independent mechanisms. Molecular Cellular Differentiation 4: 47-65, 1996. (Review)

Holbrook, N.J., Liu, Y., and Fornace, A.J. Jr.: Signaling events controlling the molecular response to genotoxic stress. In: Stress-inducible Cellular Responses; edited by Feige, U., Morimoto, R.I., Yahara, I., and Polla, B.S., Birkhauser Verlag, Basel, Switzerland, p. 273-288, 1996. (Review)

Smith, M.L. and Fornace, A.J. Jr.: Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutation Res. 340: 109-124, 1996. (Review)

Carrier, F., and A. J. Fornace, Jr. Ataxia-Telangiectasia Syndrome. p. 100-111. In Encyclopedia of Cancer, vol. 1, J. R. Bertino (ed.), Academic Press, San Diego, CA., 1996 (Review)


Kilpatrick, K. E., F. Carrier, M. L. Smith, C. Y. Chen, A. J. Lee, D. W. Rusnak, M. B. Kastan, A. J. J. Fornace, B. R. Champion, T. M. Gilmer, and et al. The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. Hybridoma 14: 355-359, 1995.

Gu, J., Dubner, R., Fornace, A.J., Jr., and Iadarola, M.J. UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation. Oncogene 11: 2175-2178, 1995.

Chen, I.T., Smith, M.L., O’Connor, P.M., and Fornace, A.J. Jr. Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. Oncogene 11: 1931-1937, 1995.

Bae, I., Fan, S., Bhatia, K., Kohn, K.W., Fornace, A.J. Jr., and O’Connor, P.M. Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following g-irradiation of human lymphoma cells. Cancer Res. 55: 2387-2393, 1995.

Kashima, N., Ueohzono, T., Fornace, A.J., Jr., and Ide, T. Induction of gadd153 in G0-specific ts mutant cells at nonpermissive temperature. Experimental Cell Res. 217: 324-328, 1995.

Zhan, Q., El-Deiry, W., Bae, I., Alamo, I. Jr., Kastan, M.B., Vogelstein, B., and Fornace, A.J., Jr. Similarity of the DNA-damage responsiveness and growth-suppressive properties of WAF1/CIP1 and GADD45. Int. J. Oncology 6: 937-946, 1995.

Bae, I., Smith, M.L., and Fornace, A.J., Jr. Induction of p53-, MDM2- and p21WAF1/CIP1-like molecules in insect cells by DNA-damaging agents. Experimental Cell Res. 217: 541-545, 1995.

Fan, S., Smith, M.L., Rivet, D.J., II, Duba, D., Zhan, Q., Kohn, K.W., Fornace, A.J., Jr., and O'Connor, P.M. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplain and pentoxifylline. Cancer Res. 8: 1649-1654, 1995.

Smith, M.L., Chen., I.T., Zhan, Q., O’Connor, P.M., and Fornace, A.J. Jr. Involvement of the p53 tumor suppressor in repair of UV-type DNA damage. Oncogene 10: 1053-1059, 1995.

Hollander, M. C. and Fornace, A.J. Jr.: Cell cycle checkpoints and growth-arrest genes activated by genotoxic stress. In: Vos, J. M. H. (eds.), DNA Repair Mechanisms: Impact on Human Diseases and Cancer, pp. 221-237, Georgetown, TX: R. G. Landes Company, 1995. (Review)

Smith, M.L. and Fornace, A.J., Jr.: Genomic instability and the role of p53 mutations in cancer cells. Current Opinion in Oncology 7: 69-75, 1995. (Review)


Hollander, M.C., Tan, K.B.,and Fornace, A.J., Jr.: Overexpression of the radiation inducible gene, GADD153, in drug-resistant Burkitt lymphoma cells. Radiation Oncology Investigations: Basic and Clinical Res. 2: 157-163, 1994.

Carrier, F., Smith, M.L., Bae, I., Kilpatrick, K.E., Chen, C.-Y., Engelstein, M., Friend, S.H., Johnson, K.J., Henner, W.D., Gilmer, T.M., Kastan, M.B., and Fornace, A.J. Jr. Characterization of human Gadd45, a p53-regulated protein. J. Biol. Chem. 269: 32672-32677, 1994.

Zhang, H., Cooney, D.A., Sreenath, A., Zhan, Q., Agbaria, R., Stowe, E.E., Fornace, A.J., Jr., and Johns, D.G.: Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content. Molecular Pharmacology 46: 1063-1069, 1994.

Smith, M.L., Zhan, Q., Bae, I., and Fornace, A.J., Jr.: Role of retinoblastoma gene product in p53-mediated DNA damage response. Experimental Cell Res. 215: 386-389, 1994.

Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D.A., O'Connor, P.M., Fornace, A. J., Jr.: Induction of BAX by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9: 3743-3751, 1994.

Fan, S., El-Deiry, W.S., Bae, I., Freeman, J., Jondle, D., Bhatia, K., Fornace, A.J., Jr., Magrath, I., Kohn, K.W., and O’Connor, P.M.: p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res. 54: 5824-5830, 1994.

Smith, M.L., Chen., I.T., Zhan, Q., Bae, I., Chen, C.Y., Gilmer, T.M., Kastan, M.B., O’Connor, P.M., and Fornace, A. J., Jr.: Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen. Science 266: 1376-1380, 1994. See also "Research News" New link found between p53 and DNA repair, Science 266: 1321-1322.

Jackman, J., Alamo, I., and Fornace, A.J., Jr.: Genotoxic stress confers preferential and coordinate mRNA stability on the five gadd genes. Cancer Res. 54: 5656-5662, 1994.

Canman, C.E., Wolff, A.C., Chen, C.Y., Fornace, A.J., Jr., and Kastan, M.B.: The p53-dependent G1 cell cycle checkpoint pathway and ataxia telangiectasia. Cancer Res. 54: 5054-5058, 1994.

Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., Fornace, A.J., Jr., and Giaccia, A.J.: Hypoxia induces the accumulation of p53 protein, but the activation of a G1-phase checkpoint by low oxygen conditions is independent of p53 status. Molec. Cell. Biol. 14: 6264-6277, 1994.

Carrier, F., McCary, J.M., Bae, I., Yarosh, D.B., and Fornace, A.J., Jr.: Activation of HIV Type 1 Long Terminal Repeat by Ultraviolet light is serum and strain specific. AIDS Res. and Human Retroviruses, 10 767-773, 1994.

Zhan, Q., Bae, I., Kastan, M.B., and Fornace, A.J. Jr.: The p53-dependent g-ray response of GADD45. Cancer Res. 54: 2755-2760, 1994.

Chen, C.Y., Oliner, J.D., Zhan, Q., Fornace, A.J. Jr., Vogelstein, B., and Kastan, M.B.: Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc. Natl. Acad. Sci. USA, 91: 2684-2688, 1994.

Zhan, Q., Lord, K.A., Alamo, I, Hollander, M.C., Carrier, F., Ron, D., Kohn, K.W., Hoffman, B., Liebermann, D., and Fornace, A.J. Jr.: The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that cooperatively suppress cell growth. Molec. Cell. Biol. 14: 2361-2371, 1994.

Carrier, F., Gatignol, A., Hollander, M.C., Jeang, K.T., and Fornace, A.J., Jr.: Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents. Proc. Natl. Acad. Sci. USA: 91: 1554-1558, 1994.


Hollander, M.C., Alamo, I., Jackman, J, Wang, M.G., McBride, O.W., Fornace, A.J., Jr.: Analysis of the mammalian gadd45 gene and its response to DNA damage. J. Biol. Chem. 268: 24385-24393, 1993.

Zhan, Q., Carrier, F, and Fornace, A.J. Jr.: Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Molec. Cell. Biol. 13: 4242-4250, 1993.

Yarosh, D. B., Alas, L., Kibitel, J., O'Connor, A., Carrier, F., and Fornace, Jr, A. J.: Cyclobutane pryrimidine dimers in UV-DNA induce release of soluble mediators which activate the human immunodeficiency virus promoter. J. Invest. Dermatol.100: 790-4, 1993.


Kastan, M.B., Zhan, Q, El-Deiry, W.S., Carrier, F, Jacks, T., Walsh, W.V., Plunkett, B.S., Vogelstein, B., and Fornace, A.J. Jr.: A mammalian cell cycle checkpoint utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71: 587-597, 1992.

Thompson, L.H., Fornace, A.J. Jr., Caldecott, K.W., Brookman, K.W., Weber, C.A., Salazar, E.S., and Takayama, K.: Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1. In DNA Repair Mechanisms, Alfred Benzon Symposium 35, edited by V.A. Bohr, K. Wassermann, and K. Kraemer. Munksgaard, Copenhagen, 42-53, 1992. (Review)

Fornace, A.J., Jr., Jackman, J., Hollander, M.C., Hoffman-Liebermann, B., and Liebermann, D.A.: Genotoxic-stress-response genes and growth-arrest genes; the gadd, MyD, and other genes induced by treatments eliciting growth arrest. Annals N.Y. Acad. Sci. 663: 139-153, 1992. (Review)

Fornace, A.J., Jr.: Mammalian genes induced by radiation; activation of genes associated with growth control. Annual Rev. Genetics 26: 507-526, 1992. (Review)  

Citron, M., Schoenhaus, M., White, A., Graver, M., Decker, R., Chen, S., Kahn, L.B., Kleynerman, L., Fornace, A.J., Jr., and Yarosh, D.: Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues. J. Natl. Cancer Inst. 84 337-340, 1992.

Park, J.S., Luethy, J.D., Wang, M.G., Fargnoli, J., Fornace, A.J., Jr., McBride, O.W., and Holbrook, N.J.: Isolation, characterization, and chromosomal localization of the human gadd153 gene (GADD153). Gene 116: 259-267, 1992.


Papathanasiou, M.A., Kerr, N., Robbins, J.H., Mc Bride, O.W., Alamo, I., Jr., Barrett, S.F., Hickson, I., and Fornace, A.J. Jr.: Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Molec. Cell. Biol. 11: 1009-1016, 1991.

Kedar, P.S., Widen, S.G., Englander, E.W., Fornace, A.J., Jr., Wilson, S.H.: The ATF/CREB transcription factor-binding site in the polymerase ß promoter mediates the positive effect of N-methyl- N'-nitro- N-nitrosoguanidine on transcription. Proc. Natl. Acad. Sci. USA 88: 3729-3733, 1991.

Papathanasiou, M. and Fornace, A.J. Jr.:  DNA-damage inducible genes.  In Drug Resistance 2, edited by Ozols, R.F., Kluwer Academic Publishers, Boston, 1991, pp. 13-36.

Papathanasiou, M. and Fornace, A.J. Jr.:  DNA-damage inducible genes.  Cancer Treat. Res. 57:  13-36, 1991

Holbrook, N.J. and Fornace, A.J., Jr.:  Response to adversity: molecular control of gene activation following genotoxic stress.  New Biologist 3:  825-834, 1991.


Fargnoli, J., Kunisada, T., Fornace, A.J., Jr., Schneider, E.L., and Holbrook, N.J.: Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc. Natl. Acad. Sci. USA 87: 846-850, 1990.

Bhatia, K., Pommier, Y., Giri, C., Fornace, A.J., Jr., Imaizumi, M., Breitman, T.R., Cherney, B.W., Smulson, M.E. Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair. Carcinogenesis 11: 123-8, 1990.

Schilder, R.J., Hall, L., Monks, A., Handel, L.M., Fornace, A.J., Jr., Ozols, R.F., Fojo, A.T., Hamilton, T.C. Metallothionein gene expression and resistance to cisplatin in human ovarian cancer. Int .J. Cancer 45: 416-422, 1990.

Hentosh, P., Collins, A.R.S., Correll, L., Fornace, A.J., Jr., Giaccia, A., and Waldren, C.A.: Genetic and biochemical characterization of the CHO-UV- 1 mutant defective in postreplication recovery of DNA. Cancer Res. 50: 2356-2362, 1990.

Fornace, A.J. Jr., Dobson, P., and Kinsella, T.: Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine. International J. Radiation Oncology Biol. Phys. 18: 873-8, 1990.

Fargnoli, J., Holbrook, N.J., and Fornace, A.J., Jr.: Low-ratio hybridization subtraction. Analytical Biochemistry 187: 364-373, 1990.

Hollander, M.C. and Fornace, A.J., Jr.: Estimation of relative mRNA content by filter hybridization to a polythymidylate probe. Biotechniques 9: 174-179, 1990.

Leuthy, J.D., Fargnoli, J., Park, J.S., Fornace, A.J., Jr., and Holbrook, N.J.: Isolation and characterization of the hamster gadd153 gene: activation of promoter activity by agents that damage DNA. J. Biol. Chem. 265: 16521-6, 1990.

Fornace, A.J. Jr., Papathanasiou, M.A., Hollander, M.C., and Yarosh, D.B.: Expression of the O6-methylguanine- DNA methyltransferase MGMT gene in mer+ and mer- human tumor cells. Cancer Res. 50: 7908-7911, 1990.

Nebert, D.W., Peterson, D.D., and Fornace, A.J. Jr.: Cellular responses to oxidative stress. Biological Oxidation Systems Vol. 1, edited by G.A. Hamilton and C.C. Reddy. Academic Press, Inc., 69-84, 1990.

Nebert, D.W., Peterson, D.D., and Fornace, A.J. Jr.: Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm. Environmental Health Perspectives 88: 13-25, 1990.

Bohr, V.A., Evans, M.K., and Fornace, A.J. Jr.: DNA repair and its pathologic implications. In Pathology Reviews, 1990, pp. 171-189, 1990.

Fornace, A.J., Jr., Papathanasiou, M.A., Tarone, R.E., Wong, M., Mitchell, J., and Hamer, D.H.  DNA-damage-inducible genes in mammalian cells.  Prog. Clin. Biol. Res. 340A:  315-25, 1990.


Fornace, A.J. Jr., Zmudka, B.Z., Hollander, M.C., and Wilson, S.H.: Induction of mammalian ß-polymerase mRNA by DNA damaging agents in Chinese hamster ovary cells. Molec. Cell. Biol. 9: 851-853, 1989.

Fornace, A.J. Jr., Alamo, I. Jr., Hollander, M.C., and Lamoreaux, E.: Ubiquitin mRNA is a major stress-induced transcript in mammalian cells. Nucleic Acids Res. 17: 1215-1230, 1989.

Hollander, M.C. and Fornace, A.J. Jr.: Induction of fos RNA by DNA damaging agents. Cancer Res. 49: 1687-1692, 1989.

Fornace, A.J. Jr., Alamo, I. Jr., Hollander, M.C., and Lamoreaux, E.: Induction of heat shock protein transcripts and B2 transcripts by various stresses in Chinese hamster cells. Experimental Cell Res. 182: 61-74, 1989.

Fornace, A.J. Jr., Nebert, D., Hollander, M.C., Papathanasiou, M., Fargnoli, J., and Holbrook, N.: Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Molec. Cell. Biol. 9:4196-4203, 1989.

Fornace, A.J. Jr.: Mechanisms and Consequences of DNA Damage Processing. UCLA Symposia on Molecular and Cellular Biology New Series, Volume 83. Review in Amer. J. Human Genetics 45: 164-165, 1989.

Bohr, V.A., Evans, M.K., and Fornace, A.J. Jr.: DNA repair and its pathologic implications. Laboratory Investigation 61: 143-161, 1989.


Nagasawa, H., Fornace, A.J. Jr., and Little, J.B.: Recovery of mitomycin C-treated mouse 10T1/2 cells during confluent holding. Mutation Res. 198: 153-160, 1988.

Zmudka, B.Z., Fornace, A., Collins, J., and Wilson, S.H.: Characterization of DNA polymerase ß mRNA: cell-cycle and growth response in cultured human cells. Nucleic AcidsRes. 16: 9587-9596, 1988.

Fornace, A.J. Jr., Schalch, H., and Alamo, I. Jr.: Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation. Molec. Cell. Biol. 8: 4716-4720, 1988.

Fornace, A.J. Jr., Alamo, I. Jr., and Hollander, M.C.: DNA damage-inducible transcripts in mammalian cells. Proc. Natl. Acad. Sci. USA 85: 8800-8804, 1988.


Kinsella, T.M., Dobson, P.P., Mitchell, J.B., and Fornace, A.J., Jr.: Enhancement of X ray induced DNA damage by pre-treatment with halogenated pyrimidine analogs. Int. J. Radiation Oncology Biol. Phys. 13: 733-739, 1987.

Kinsella, T.M., Dobson, P.P., Fornace, A.J., Jr., Barrett, S.F., Ganges, M.B., and Robbins, J.H.: Alzheimer's disease fibroblasts have normal repair of N-methyl- N'-nitro- N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique. Biochem. Biophys. Res. Comm. 149: 355-361, 1987.


Fornace, A.J., Jr., Kinsella, T., Dobson, P., and Mitchell, J.B.: Repair of ionizing radiation DNA base damage in ataxia telangiectasia cells. Cancer Res. 46: 1703-1706, 1986.

Fornace, A.J., Jr., Dobson, P., and Kinsella, T.: Repair of -ray- induced-base damage in xeroderma pigmentosum cells. Radiation Res. 106: 73-77, 1986.

Fornace, A.J., Jr., Dobson, P.P., and Kinsella, T.: Analysis of the effect of DNA alkylation on alkaline elution. Carcinogenesis 7: 927-932, 1986.

Fornace, A.J., Jr., and Mitchell, J.B.: Induction of B2 RNA polymerase III transcription by heat shock; enrichment for heat shock induced sequences in rodent cells by hybridization subtraction. Nucleic Acids Res. 14: 5793-5811, 1986.

Kinsella, T., Dobson, P.B., Russo, A., Mitchell, J.B., and Fornace, A.J., Jr.: Modulation of X-ray DNA damage by SR-2508 + buthionine sulfoximine. Int. J. Radiation Oncology Biol. Phys. 12: 1127-1130, 1986.


Kant, J.A., Fornace, A.J., Jr., Saxe, D., Simon, M.I., McBride, O.W., and Crabtree, G.R.: Evolution and organization of the fibrinogen locus on chromosome 4: Gene duplication accompanied by transposition and inversion. Proc. Natl. Acad. Sci. 82:2344-2348, 1985.

Yarosh, D., Fornace, A.J., Jr., and Day, R.: Human O6-alkylguanine- DNA alkyltransferase fails to repair O4-methylthymidine and methyl phosphotriesters in DNA as does the alkyltransferase from E. coli. Carcinogenesis 6: 949-953, 1985.

Crabtree, G.R., Comeau, C.M., Fowlkes, D.M., Fornace, A.J., Jr., Malley, J.D., and Kant, J.: Evolution and structure of the fibrinogen genes: random insertion of introns or selective loss? J. Mol. Biol. 185: 1-19, 1985.

Fornace, A.J., Jr., and Jaffe, E.S.: Pathology of malignant lymphomas. In Neoplastic Diseases of the Blood and Blood-forming organs, edit. Wiernik, P.H., Canellos, G.P., Kyle, R.A., and Schiffer, C.A.; Churchill Livingstone Inc., 1985, pp. 707-736.


Holbrook, N.J., Smith, K.A., Fornace, A.J., Jr., Comeau, C.C., Wiskocil, R.L., and Crabtree, G.R.: T cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc. Natl. Acad. Sci 81: 1634-1638, 1984.

Fornace, A.J., Jr., Cummings, D.E., Comeau, C.M., Kant, J.A., and Crabtree, G.R.: Single-copy inverted repeats associated with regional genetic duplications in fibrinogen and immunoglobulin genes. Science 224: 161-164, 1984. 

Mitchell, J.B., Morstyn, G., Russo, A., Kinsella, T.J., Fornace, A.J., Jr., McPherson, S., and Glatstein, E.: Differing sensitivity to fluorescent light in Chinese hamster cells containing equally incorporated quantities of BUdR versus IUdR. Int. J. Radiation Oncology Biol. Phys. 10: 1447-1451, 1984.

Grafstrom, R.C., Fornace, A.J., Jr., and Harris, C.C.: Repair of DNA damage caused by formaldehyde in human cells. Cancer Res. 44: 4323-4327, 1984.

Fornace, AJ, Jr., Cummings, D, Comeau, CM, Kant, J, and Crabtree, GR: Structure of the human fibrinogen gene: alternate mRNA splicing near the 3'end of the gene producesA and B forms of fibrinogen. J. Biol. Chem. 259: 12826-12830, 1984.


Fornace, A.J., Jr., and Seres, D.S.: Detection of DNA single-strand breaks during the repair of ultraviolet damage in xeroderma pigmentosum cells. Radiat. Res. 93: 107-111, 1983.

Grafstrom, R.C., Fornace, A.J., Jr., Autrup, H., Lechner, J.F., and Harris, C.C.: Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220: 216-218, 1983. 

Crabtree, G. R., Kant, J. A., Fornace, A. J. J., Rauch, C. A., and Fowlkes, D. M. Regulation and characterization of the mRNAs for the A alpha, B beta and gamma chains of fibrinogen. Ann. N. Y. Acad. Sci. 408: 457-468, 1983. PMID: 6575701.

Fornace, A.J., Jr.: Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells. Nature 304: 552-4, 1983.

Henson, P., Fornace, A.J., Jr., and Little, J.B.: Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome. Mutation Research 112: 383-395, 1983.


Fornace, A.J., Jr.: Detection of DNA single-strand breaks produced during the repair of damage by DNA-protein cross-linking agents. Cancer Res. 42: 145-149, 1982.

Fornace, A.J., Jr.: Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution. Mutation Res. 94: 263-276, 1982.

Fornace, A.J., Jr., and Seres, D.S.: Repair of trans-Pt(II) diamminedichloride DNA-protein crosslinks in normal and excision-deficient human cells. Mutation Res. 94: 277-284, 1982.

Seres, D.S., and Fornace, A.J., Jr.: Normal response of Fanconi's anemia cells to high concentrations of 02 as determined by alkaline elution. Biochim. Biophys. Acta 698: 237-242, 1982.

Nagasawa, H., Fornace, A.J., Jr., Ritter, M.A., and Little, J.B.: Relationship of enhanced survival during confluent holding recovery in ultraviolet-irradiated human and mouse cells to chromosome aberrations, sister chromatid exchanges, and DNA repair. Radiat. Res. 92: 483-496, 1982.

Fornace, A.J., Jr., Lechner, J.F., Grafstrom, R., and Harris, C.C.: DNA repair in human bronchial epithelial cells. Carcinogenesis 3: 1373-1377, 1982.


Fornace, A.J., Jr., Seres, D.S., Lechner, J.F., and Harris, C.C.: DNA-protein cross-linking by chromium salts. Chem.-Biol. Interactions 36: 345-354, 1981.


Fornace, A.J., Jr., Nagasawa, H., and Little, J.B.: Relationship of sister chromatid exchanges, chromosome aberrations, DNA repair, and survival during liquid holding recovery in X-irradiated mammalian cells. Mutation Res. 70: 323-336, 1980.

Fornace, A.J., Jr., and Little, J.B.: Normal repair of DNA single-strand breaks in ataxia telangiectasia. Biochim. Biophys. Acta 607: 432-437, 1980.

Fornace, A.J., Jr., and Little, J.B.: Malignant transformation by the DNA-protein crosslinking agent, trans-Pt(II) diamminedichloride. Carcinogenesis 1: 989-994, 1980.

Fornace, A.J., Jr. Relationship of DNA repair and chromosome aberrations to potentially lethal damage repair in X-irradiated mammalian cells. In DNA Repair and Mutagenesis in Eukaryotes. Plenum Press, l980, pp. 267-283.


Fornace, A.J., Jr., and Little, J.B.: DNA-protein crosslinking by chemical carcinogens in mammalian cells. Cancer Res. 39: 704-710, 1979.

Fornace, A.J., Jr., Little, J.B., and Weichselbaum, R.: DNA repair in Fanconi's anemia fibroblasts.Biochim. Biophys. Acta 561: 99-109, 1979.


Fornace, A.J., Jr., Kohn, K.W., and Kann, H.E., Jr.: Inhibition of the ligase step in excision repair by 2-chloroethyl isocyanate, a decomposition product of BCNU. Cancer Res. 38: 1064-1069, 1978.


Fornace, A.J., Jr., and Little, J.B.: DNA crosslinking induced by X-rays and chemical agents. Biochim. Biophys. Acta 477: 343-355, l977.


Fornace, A.J., Jr., Kohn, K.W., and Kann, H.E., Jr.: DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. Proc. Natl. Acad. Sci. USA 73: 39-43, 1976.

Fornace, A.J., Jr., and Kohn, K.W.: DNA-protein crosslinking by UV radiation in normal human and xeroderma pigmentosum fibroblasts. Biochim. Biophys. Acta 435: 95-l03, l976.

Iqbal, Z., Kohn, K.W., Ewig, R.E., and Fornace, A.J., Jr.: Single-strand scission and repair of DNA in mammalian cells by bleomycin. Cancer Res. 36: 3834-3838, l976.