Suman S, Kumar S, Fornace AJ Jr, Datta K. The effect of carbon irradiation is associated with greater oxidative stress in mouse intestine and colon relative to γ-rays. Free Radic Res. 2018 May;52(5):556-567. doi: 10.1080/10715762.2018.1452204.
Kumar, M. A. S., Laiakis, E. C., Ghandhi, S. A., Morton, S. R., Fornace, A. J., Jr, and Amundson, S. A. Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays. Radiat Res 2018. PMID: 29746213

Kumar, S., Suman, S., Fornace, A. J., Jr, and Datta, K. Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine. Proc Natl Acad Sci U S A 201807522, 2018. PMID: 30275302 PMCID: PMC6196540


Suman S, Kumar S, Moon BH, Fornace AJ Jr, Kallakury BVS, Datta K. Increased Transgenerational Intestinal Tumorigenesis in Offspring of Ionizing Radiation Exposed Parent APC1638N/+ Mice. J Cancer. 2017 Jul 1;8(10):1769-1773. doi: 10.7150/jca.17803. eCollection 2017.

Suman S, Kumar S, Moon BH, Fornace AJ Jr, Datta K. Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice. Life Sci Space Res (Amst). 2017 May;13:45-50. doi: 10.1016/j.lssr.2017.04.003. Epub 2017 Apr 29.

Shuryak I, Fornace AJ Jr, Datta K, Suman S, Kumar S, Sachs RK, Brenner DJ. Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex. Radiat Res. 2017 Apr;187(4):476-482. doi: 10.1667/RR009CC.1. Epub 2017 Feb 20.


Suman S, Kumar S, Fornace AJ, Datta K. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine. Sci Rep. 2016 Aug 25;6:31853. doi: 10.1038/srep31853. PMID: 27558773.

Datta K, Suman S, Kumar S, Fornace AJ Jr. Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway. J Cancer. 2016 Jan 1;7(2):174-83. doi: 10.7150/jca.13387. eCollection 2016. Review. PubMed PMID: 26819641; PubMed Central PMCID: PMC4716850.

Suman S, Kumar S, Moon BH, Strawn SJ, Thakor H, Fan Z, Shay JW, Fornace AJ Jr, Datta K. Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorgenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice. 2016 May 1;95(1):131-8. doi: 10.1016/j.ijrobp.2015.10.057. Epub 2015 Oct 31. PMID: 26725728.

Norbury, J. W., Schimmerling, W., Slaba, T. C., Azzam, E. I., Badavi, F. F., Baiocco, G., Benton, E., Bindi, V., Blakely, E. A., Blattnig, S. R., Boothman, D. A., Borak, T. B., Britten, R. A., Curtis, S., Dingfelder, M., Durante, M., Dynan, W. S., Eisch, A. J., Robin Elgart, S., Goodhead, D. T., Guida, P. M., Heilbronn, L. H., Hellweg, C. E., Huff, J. L., Kronenberg, A., La Tessa, C., Lowenstein, D. I., Miller, J., Morita, T., Narici, L., Nelson, G. A., Norman, R. B., Ottolenghi, A., Patel, Z. S., Reitz, G., Rusek, A., Schreurs, A. S., Scott-Carnell, L. A., Semones, E., Shay, J. W., Shurshakov, V. A., Sihver, L., Simonsen, L. C., Story, M. D., Turker, M. S., Uchihori, Y., Williams, J., and Zeitlin, C. J. Galactic cosmic ray simulation at the NASA Space Radiation Laboratory. Life Sci Space Res (Amst) 8: 38-51, 2016. PMID: 26948012. 

El-Ashmawy, M., Coquelin, M., Luitel, K., Batten, K., and Shay, J. W. Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells. Sci Rep 6: 31669, 2016. PMID: 27539227 PMCID: PMC4990973.

Hendry, J. H., Niwa, O., Barcellos-Hoff, M. H., Globus, R. K., Harrison, J. D., Martin, M. T., Seed, T. M., Shay, J. W., Story, M. D., Suzuki, K., and Yamashita, S. ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection. Ann ICRP 45: 239-252, 2016. PMID: 26956677.


Suman S, Kallakury BV, Fornace AJ Jr, Datta K. Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure. Int J Biol Sci. 2015 Jan 20;11(3):274-83. doi: 10.7150/ijbs.10684. eCollection 2015. PubMed PMID:25678846; PubMed Central PMCID: PMC4323367.

Suman S, Kumar S, Fornace AJ Jr, Datta K. Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors. Front Oncol. 2015 Oct 8;5:218. doi: 10.3389/fonc.2015.00218. eCollection 2015. PubMed PMID: 26500891; PubMed Central PMCID: PMC4597120.

Kim, S. B., Bozeman, R. G., Kaisani, A., Kim, W., Zhang, L., Richardson, J. A., Wright, W. E., and Shay, J. W. Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. Oncogene 2015. PMID: 26477319 

Suman S, Kumar S, Moon BH, Strawn SJ, Thakor H, Fan Z, Shay JW, Fornace AJ Jr, Datta K. Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice. Int J Radiat Oncol Biol Phys. 2015 Oct 31. pii: S0360-3016(15)26654-0. doi: 10.1016/j.ijrobp.2015.10.057. [Epub ahead of print] PubMed PMID: 26725728.

Niwa, O., Barcellos-Hoff, M. H., Globus, R. K., Harrison, J. D., Hendry, J. H., Jacob, P., Martin, M. T., Seed, T. M., Shay, J. W., Story, M. D., Suzuki, K., Yamashita, S., and ICRP. ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection. Ann ICRP 44: 7-357, 2015. PMID: 26637346 .


Delgado, O., Batten, K. G., Richardson, J. A., Xie, X. J., Gazdar, A. F., Kaisani, A. A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W. E., Story, M. D., Wistuba, I. I., Minna, J. D., and Shay, J. W. Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res 20: 1610-1622, 2014. PMID: 24486591 PMCID: PMC3961755

Datta, K., Suman, S., Shay, J. W., and Fornace, A. J., Jr. Developing omics-based approaches for short- and long-term space radiation risk assessment. The Health Risks of Extraterrestrial Environments (THREE), 2014. 

Cheema AK, Suman S, Kaur P, Singh R, Fornace AJ Jr, Datta K. Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure. PLoS One. 2014 Jan 27;9(1):e87079. doi: 10.1371/journal.pone.0087079. eCollection 2014.

Datta K, Suman S, Fornace AJ Jr. Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine. Int J Biochem Cell Biol. 2014 Dec;57:167-76. doi:10.1016/j.biocel.2014.10.022. Epub 2014 Oct 23. PubMed PMID: 25449263; PubMed Central PMCID: PMC4363107.

Trani D, Nelson SA, Moon BH, Swedlow JJ, Williams EM, Strawn SJ, Appleton PL, Kallakury B, Näthke I, Fornace AJ Jr. High-energy particle-induced tumorigenesis throughout the gastrointestinal tract. Radiat Res. 2014 Feb;181(2):162-71. doi: 10.1667/RR13502.1.

Suman S, Moon BH, Thakor H, Fornace AJ Jr, Datta K. Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality. Radiat Res. 2014 Sep;182(3):345-9. doi: 10.1667/RR13770.1. Epub 2014 Aug 12. PubMed PMID: 25117622.

Kim, S. B., Kaisani, A., and Shay, J. W. Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer. J Radiation Res in press, 2014. 

Kim, S. B., Zhang, L., Barron, S., and Shay, J. W. Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation. Life Sciences in Space Radiation in press, 2014. 

El-Ashmawy, M., Delgado, O., Cardentey, A., Wright, W. E., and Shay, J. W. CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation. PLoS One 9: e115600, 2014. PMID: 25536195 PMCID: PMC4275221.


Suman S, Rodriguez OC, Winters TA, Fornace AJ Jr, Albanese C, Datta K. Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production. Aging (Albany NY). 2013 Aug;5(8):607-22.


Datta, K., Hyduke, D. R., Suman, S., Moon, B. H., Johnson, M. D., and Fornace, A. J. J. Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland. Radiat Oncol 7: 205, 2012.

Datta, K., Suman, S., Kallakury, B. V., and Fornace, A. J., Jr. Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS ONE 7: e42224, 2012.

Datta, K., Suman, S., Kallakury, B. V., and Fornace, A. J., Jr. Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater beta-Catenin Activation than gamma Radiation in APC(Min/+) Mice. PLoS ONE 8: e59295, 2013.

Datta, K., Suman, S., Trani, D., Doiron, K., Rotolo, J. A., Kallakury, B. V., Kolesnick, R., Cole, M. F., and Fornace, A. J., Jr. Accelerated hematopoietic toxicity by high energy (56)Fe radiation. Int. J. Radiat. Biol. 88: 213-222, 2012.

Suman, S., Datta, K., Trani, D., Laiakis, E. C., Strawn, S. J., and Fornace, A. J. J. Relative biological effectiveness of (12)C and (28)Si radiation in C57BL/6J mice. Radiat. Environ. Biophys. 51: 303-309, 2012.

Suman, S., Fornace, A. J. Jr., and Datta, K. Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development, in Colorectal Cancer - From Prevention to Patient Care, Rajunor Ettarh (Ed.), 277-300, 2012; ISBN: 978-953-51-0028-7.

Suman, S., Johnson, M. D., and Fornace, A. J., Jr. Exposure to Ionizing Radiation Causes Long-Term Increase in Serum Estradiol and Activation of PI3K-Akt Signaling Pathway in Mouse Mammary Gland. Int J Radiat Oncol Biol Phys 84: 500-507, 2012.

Trani, D., Moon, B. H., Kallakury, B., Hartmann, D. P., Datta, K., and Fornace, A. J., Jr. Sex-dependent Differences in Intestinal Tumorigenesis Induced in Apc1638N/+ Mice by Exposure to Gamma Rays. Int. J. Radiat. Oncol. Biol. Phys. in press: 2012.